Careers

Voyager is looking for exceptional individuals who share our passion for developing life-changing gene therapies for CNS disorders.

About Voyager Therapeutics

 

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

Voyager Therapeutics is seeking an exceptional candidate for a Senior Clinical Trial Manager who will work closely with internal team members and vendors to ensure that assigned clinical trials are conducted per protocol, in a timely fashion and in a manner compliant with SOPs, ICH/GCP/regulatory guidelines, company goals and established study budgets. This position reports to the Senior Director of Clinical Operations.

Responsibilities:

  • Comprehensive oversight of day-to-day operational aspects of assigned clinical trial(s)

  • Management of Clinical Research Organization (CRO) interactions, including sponsor oversight of relevant functional activities (e.g., study management, monitoring, site management, and project master files).

  • Works with CRO to develop and/or revise scope of service agreements, budgets, plans and detailed timelines and ensures that performance expectations are met.

  • Monitoring of study progress: ensuring compliance with relevant regulations and guidelines by maintaining regular contact with external vendors, including CRAs as applicable.

  • Completing sponsor's review of monitoring reports and periodic review of data quality.

  • Identifying potential study issues, and proactively recommending and implementing solutions or corrective actions as needed.

  • Serving as a liaison and resource for investigational sites; reviewing investigator contracts and site payments.

  • Occasionally travelling to CRO/vendor facilities and/or investigative sites to train and assess study team and CRAs.

  • Organizing and managing internal team meetings and other trial-specific meetings.

  • Participating in the development, review and implementation of departmental SOPs and processes.

  • Other Job related duties as assigned.

Qualifications:

  • BS/BA degree in science or similar area.

  • 5 to 7 years of experience required managing clinical trials for or within the biotech or pharmaceutical industry, including CRO/vendor management, monitoring of budget scope, clinical site monitoring, and knowledge of basic data management/biostatistics processes including Electronic Data Collection (EDC) and Pharmacovigilance

  • In-depth knowledge of clinical research operations, including interpretation and implementation of FDA regulations/ICH guidelines, is required.

  • Excellent oral and written communications.

  • Strong computer skills including knowledge of Microsoft Excel, Word, Powerpoint and Outlook.

  • Ability to work within established timelines, in a fast paced environment.

  • Excellent organizational and priority management skills.

  • Good interpersonal skills and ability to deal with people at all levels with sensitivity and tact.

  • Prior CNS or gene therapy experience preferred.

 

 

 

 

 

 

About Voyager Therapeutics

 Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

 

Senior Network Engineer

The IT and Informatics group at Voyager Therapeutics is looking for an experienced professional to manage Voyager’s IT infrastructure to support the discovery and development of gene therapies. The individual will report to the Director of Informatics & IT and be responsible for managing the network infrastructure, Help Desk, and other IT functions. This individual will report with the Director to build a long term IT strategy and manage IT budget.

 

Responsibilities

  • Managing Voyager’s network infrastructure both on-premises and in the cloud to ensure efficient operations and negligible disruptions to the business
  • Manage relationships with key IT vendors to execute IT projects and provide support
  • Coordinate the Help Desk function with Voyager’s preferred MSP to ensure quality support for Voyager staff within Service Level Agreements. Computing support includes both office and lab environments
  • Act as the project lead on various IT initiatives including information security, Cloud Computing, Windows 10 migration
  • Manage IT support and project spending to a budget
  • Develop IT policies for monitoring controls according to COBIT framework

 

Requirements

  • BS/BA with 8+ years of experience in industry
  • Strong focus on customer satisfaction
  • 5+ years project management experience with a proven track record to deliver value on IT projects working with cross-functional teams
  • Ability to be flexible working on multiple projects with a variety of roles
  • Experience managing vendors and third party contractor companies
  • Technical skills and experience working with Active Directory, PowerShell, Microsoft O365, Amazon Web Services (AWS), Hybrid environment, Help Desk, JIRA, Mimecast
  • Manage multiple sites

 

Desired Skills

  • Experience with Information Security technologies including intrusion detection, log management, MDM
  • Experience Windows migration and computing lifecycle refreshes
  • LINUX/Windows System Administration
  • Oracle Database Administration
  • Experience working with scientists in the domains of gene therapy
  • Experience managing a department budget
  • Negotiation skills especially on contract terms and pricing

 

 

 

 

 

 

 

 

About Voyager Therapeutics

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

 

Senior Medical Director, Neurosciences

The Medical Director will lead the formulation of clinical development plans and the planning, execution, analysis and interpretation of all clinical studies to support those plans. The candidate will lead cross-functional teams to generate, deliver, and disseminate high-quality clinical data supporting the overall development strategy for one or more programs.  The initial focus will be on CNS indications currently in the Voyager pipeline.

 

Responsibilities include, but not limited to; 

  • Provide strategic medical leadership that integrates knowledge in gene therapy, basic and clinical neuroscience
  • Formulate clinical development plans (CDP) that integrate scientific rationale, clinical need, clinical measurement approaches, statistical rigor, regulatory and payor requirements, and company strategy
  • Develop and implement high quality clinical studies to support the CDP including biomarker and translational studies, natural history studies, and clinical trials
  • Participate in interpretation of data analyses of clinical trial results and authoring clinical trial reports
  • Provide medical input into regulatory document preparation
  • Direct publication planning, advisory board meetings and training programs
  • Lead clinical study teams
  • Provide medical monitoring, safety assessment and overall oversight for all clinical studies supporting the CDP
  • Establish and operate within appropriate timelines and   budgets for clinical studies
  • Develop and maintain strong relationships with program counterparts in internal functions as well as external collaborative relationships
  • Present at investigator meetings, advisory meetings, regulatory meetings, and represent Voyager at professional meetings
  • Contribute medical leadership and guidance to business development efforts

 

Essential Requirements:

  • Medical Doctor (M.D.), Doctor of Osteopathy (D.O.), or non-US equivalent of M.D. degree with specialty training in neurology or a neuroscience field
  • Minimum 7 years of clinical trial experience and at least 3 years of pharmaceutical/biotechnology clinical development experience in neuroscience. Pediatric development experience is a plus
  • Extensive knowledge of clinical trial methodology, regulatory and compliance requirements governing clinical trials, and experience in development of clinical strategy and the design of study protocols. Formal training in clinical research methods is a plus
  • Must possess excellent oral and written English communication skills
  • High integrity and proven leadership skills and ability to bring out the best in others on a cross-functional team
  • Ability to prioritize across several complex clinical research studies and programs
  • Demonstrated strategic and critical thinking skills
  • Ability to interact externally and internally to support the scientific and business strategy
  • Ability to exercise judgment and address complex problems and create solutions across multiple projects 

 

Interested candidates should apply at – careers@voyagertherapeutics.com

About Voyager Therapeutics

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

Research Associate - Neuroscience  ( in -vivo )

 

Voyager Therapeutics seeks an experienced and highly motivated junior level in vivo research Associate to contribute to its research team at its facility in Cambridge, Massachusetts. This is an ideal position for an individual with excellent in vivo skills in basic rodent procedures and rodent surgery, who thrives in a team-oriented, fast-paced, and cross-disciplinary start-up biotech environment. This is a hands-on position for a person committed to helping the group conduct innovative drug discovery research while meeting deadlines and company goals. We are seeking a person who is enthusiastic about biomedical research, is capable of working independently, as well as collaboratively with other scientists and team members. Successful candidates should have extensive prior hands-on expertise with small animal handling and manipulation/restraint to include procedures not limited to in vivo: dosing, measuring, weighing, and surgeries, necropsy, sampling which may include PK/PD and tissue preparation for histology analysis. The candidate should also be able to independently execute experiments and have good communication and interpersonal skills. Prior hands-on experience in qRT-PCR, western, and/or ELISA methods is a plus.

 

Requirements:

  • B.S.  Life Sciences or related 
  • 3-5   In vivo experience in the biotech/pharmaceutical industry is preferred
  • Minimum 3 years of a hand-on laboratory experience with in a range of in vivo techniques including rodent handling, administration of therapeutic agents by various routes (i.e. IV, IP, etc.), observation, transcardial perfusion, blood collection, necropsy and tissue collection and tissues preparation for biochemical assays is required.
  • Experience with stereotaxic surgery, and CNS tissue collection is a plus. 
  • Experience with animal study design, documentation, execution of experiments and data analysis
  • Ability to be highly productive in a fluid and fast-paced work environment
  • The candidate must be team oriented, self-motivated with strong organizational skills.

Strongly Preferred:

  • Experience on cross-functional therapeutic program team
  • Experience within a start-up or small biotech environment

 

 

About Voyager Therapeutics

 

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

 

Research Associate, Process Development ( Downstream Focus )

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Developing robust and reliable vector production processes is central for establishing successful gene therapy applications.  Voyager is seeking a highly motivated Research Associate to join the Process Development group with a downstream purification focus. The qualified candidate will carry out process development activities for the manufacture of pre-clinical and cGMP grade rAAV products.  In addition, the candidate will also participate in internal production activities and analytical assays that are related to the experiments being completed.  The ability to report the results of this work in a concise and well documented manner are important aspects of the position. 

Responsibilities:

  • Perform benchtop and preparative separations of rAAV particles from invertebrate and mammalian cells using various filtration, TFF, centrifugation and chromatographic techniques.
  • Develop protocols for viral genome\capsid purification using column and capsule chromatography using Akta protein purification systems.
  • Complete concentrations and diafilitrations using hollow fibers and small plate and frame UF\DF systems.
  • Make reagents and solutions required for production protocols
  • Maintain and update databases for reagents
  • Conduct quality control assays for purity and quantification, including agarose gel electrophoresis, endotoxin, and purity by UV absorbance
  • Protein analysis including both quantitative and qualitative assays, e.g., ELISA, protein activity assays, western blots, and silver stained PAGE
  • Provide support for the transfer of developed protocols to internal and external manufacturing parties

 

Requirements:

Bachelor’s degree in biology, biochemistry, chemistry, biotechnology, chemical engineering and related fields

Minimum 2-3 years of laboratory experience performing experiments

Previous experience working with protein biologics or vaccines is a must, prior experience working with AAV desired

Experience with virus purification or protein purification, including the use of Akta systems, UF\DF systems, and cell filtration devices

Strong desire to learn multiple new techniques and willingness to provide support to more senior research personnel as required

Significant attention to detail and accuracy in developing and following protocols

Ability to be highly productive in a fluid, fast-paced and teamwork environment

 

 

 

About Voyager Therapeutics

 

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

Senior / Research Associate, Molecular Biology- Vector Engineering

Voyager Therapeutics Vector Engineering Team is seeking a highly motivated Senior Research Associate with molecular and cellular biology techniques to provide  assistance to scientists and work as a part of the vector engineering group.The successful candidate will work largely independently on a daily basis, and yet work closely with the scientist who supervises his/her work.

The individual will be responsible for performing molecular biology and cell biology work, including mammalian cell culture, cell transfection, DNA/RNA extraction from cells and animal tissues, RT-PCR, qPCR, DNA plasmid construction, production and purification. The qualified candidate will also carry out rAAV vector production, purification and quantification etc. In addition, this person will perform Western blot, ELISA assays and SDS-PAGE. This position reports to the Senior Scientist, Vector Engineering.

 

Requirements

 

  • B.S in Biology or Biochemistry or MA in Molecular Biology/ Biochemistry

  • 3-5 years  experience virus/protein purification preferred

  • Preferred experience with viral vectors is preferred, but not essential                                                                       

  • Previous hands-on experience with molecular and cellular techniques is preferred

  • Excellent organizational, critical thinking skills, lab notebook practices and attention to detail are essential

  • Excellent communication skills, with the ability to interact with all levels of staff and with external contacts

  • Ability to accurately synthesize data analysis, communicate and present to broader audience

  • Ability to perform multiple tasks with a well-organized manner

 

Additional Qualifications

 

  • Prepare the required materials (plasmids, reagents, cells, etc)

  • Document, compile, and analyze experimental data

  • Attends and actively contribute to team meetings, share results, plan projects and experiments

 

 

 

 

 

Research Associate – Quality Control

 

About Voyager Therapeutics

 

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advancing the field of AAV (adeno-associated virus) gene therapy through innovation and investment in vector engineering and optimization, manufacturing and dosing and delivery techniques. The company’s pipeline is focused on severe CNS diseases in need of effective new therapies, including advanced Parkinson’s disease, a monogenic form of amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia, Huntington’s disease and spinal muscular atrophy (SMA). Voyager has broad strategic collaborations with Sanofi Genzyme, the specialty care global business unit of Sanofi, and the University of Massachusetts Medical School. Our founders include scientific and clinical leaders in the fields of adeno-associated virus (AAV) gene therapy, expressed RNA interference and neuroscience. Our management team has deep expertise and a track record of building exceptional life science companies.

 

Voyager Therapeutics is developing recombinant adeno-associated virus (rAAV) vectors for treating neurological diseases. Thorough characterization of these products is essential for establishing successful gene therapy applications. Voyager is seeking a highly motivated Research Associate for a position within the quality control group. The qualified candidate will follow SOPs and relevant procedures involved in analysis of research and pre-clinical grade materials (rAAV, Baculovirus, and DNA). After product testing, the candidate will be responsible for data analysis as well as reporting of data. This position reports to the Manager of Quality Control.

 

  • Independently, conduct quality control assays (purity, identity, strength, and quantification) for in-process and final products

  •  Perform routine assays on a weekly basis to determine product quality

  • Analyze data and record results into ELN/LIMS in a timely manner

  • Formulation and testing of buffers and materials needed for routine assays

  • Perform both qualitative and quantitative analysis of proteins: (ELISA, Western blot, silver stain/PAGE) and DNA (qPCR, agarose gel electrophoresis)

  • Revise and edit standard operating procedures

  • Further develop existing methods for improved performance

 

Qualifications

  •  Bachelor’s in Biochemistry/Biology/Chemistry/Virology or a related field
  • 5-7 years lab experience and 1-2 years of relevant QC experience ideal

  • Experience with the following techniques is important for qualifying for this position: qPCR, ELISA, PAGE

  • Strong desire to learn multiple techniques and willingness to provide support as required

  • Significant attention to detail and accuracy in following protocols

  • Demonstrated ability to be highly productive in a fluid, fast-paced and team work environment

 

Strongly Preferred

  •  Experience with Ultracentrifugation and Bioburden assays

  •   Experience in assay development

  •   Experience working in a GLP/GMP regulated environment

  •   Aseptic technique and maintenance of cell cultures

  •   Experience with drug development within a start-up or small biotech environment

  •   Excellent record on working in cross-functional therapeutic program teams

 

To Apply, or learn more about career opportunities at Voyager Therapeutics: Please forward an updated CV, contact information and Job Title in the subject line to:careers@voyagertherapeutics.com

Note to Employment Agencies: Please do not forward agency resumes. Voyager Therapeutics is not responsible for any fees related to resumes that are unsolicited and out of executed contracts.

Voyager Therapeutics will only accept job applications from candidates who are properly documented with authorization to work in the United States.

Equal Opportunity Employer M/F/D/V